Enquiries & Appointments

pic3

RESEARCH AND PUBLICATIONS

Dr Sherman is one of 2 principal investigators of an ongoing research programme on the non-invasive assessment of liver disease, which has been awarded local and national grants, and has resulted in a number of publications and presentations to national and international specialist conferences. He is the author of many publications in the following areas :

  • Non-invasive assessment of liver disease (elastography)
  • Other areas of hepatology and gastroenterology
  • Alcohol-related liver damage and its management

NON-INVASIVE ASSESSMENT OF LIVER DISEASE (ELASTOGRAPHY)

Abstracts

M Jagtiani, P Shorvon, P Bassett, K Kandiah, P Tadrous, D Sherman. Ultrasound elastography with concomitant liver biopsy: Comparison of ARFI elastography measurement with histopathological grading. Oral presentation at the Radiological Society of North America meeting, Chicago, November 2013.

D Sherman, M Jagtiani, P Basset, D Abeles, O Kemp, P Shorvon. Factors contributing to variance between ARFI elastography and liver histology: results of a large unselected consecutive series with simultaneous biopsy of ARFI measurement site. Submitted for presentation to EASL 2014 meeting, London

D Sherman, M Jagtiani, A Sharif, P Basset, P Shorvon. High accuracy for non-invasive prediction of portal hypertension using single session ARFI elastography + ultrasound SPVD score: results of a prospective protocol-based single centre study. Poster presentations at: a) European Association for the Study of Liver Disease meeting, Amsterdam, April 2013 and b) British Association for the Study of Liver Disease meeting,, London, September 2013

D Sherman, K Kandiah, M Jagtiani, A Sharif, P Basset,P Shorvon  A “Real World” controlled study of liver stiffness measured by ARFI (Acoustic Radiation Force Impulse) elastography in hospitalized patients with decompensated Alcoholic Liver Disease (ALD): A new paradigm in assessment of severity and prognosis? Poster presentations at: a) Digestive Diseases Week / American Gastroenterological Association meeting (AGA/DDW 2012), San Diego, USA May 2012 and b) British Society of Gastroenterology / Digestive Diseases Federation Liverpool, June 2012

D Sherman, K Kandiah, M Jagtiani, A Sharif, P Shorvon. A new paradigm in the non-invasive assessment of portal hypertension: A Single Ultrasound Procedure including Acoustic Force Impulse (ARFI) elastography predicts over 90% of oesophago-gastric varices and portal gastropathy.  Poster presentations at: a) Digestive Diseases Week / American Gastroenterological Association meeting  (AGA/DDW 2012), San Diego, USA May 2012 and b) British Society of Gastroenterology / Digestive Diseases Federation Liverpool, June 2012

K Kandiah, MJ Sangwaiya, P Tadrous, P Shorvon, D Sherman. Role of Acoustic Radiation Force Impulse (ARFI) elastography in the non-invasive assessment of liver fibrosis in chronic viral hepatitis: A simultaneous comparison with liver histology in a secondary care setting. Poster presentation at British Association for the Study of the Liver (BASL) Annual Meeting 2011, London.

K Kandiah, MJ Sangwaiya, P Tadrous, P Shorvon, D Sherman. Role of Acoustic Radiation Force Impulse (ARFI) elastography in the non-invasive assessment of liver fibrosis in chronic viral hepatitis: A simultaneous comparison with liver histology in a secondary care setting.  Poster presentation (abstract number 1139485) at the American Association of the Study of Liver Diseases (AASLD) Meeting 2011, San Franscisco, USA.

MJ Sangwaiya, P Bassett, D Sherman, P Shorvon. Fat fibrosis correlation with Acoustic Radiation Force Impulse – Are larger patients prone to higher variability in elastography readings? Oral presentation at European Society of Gastrointestinal and Abdominal Radiology (ESGAR) meeting May 2011, Venice, Italy

MJ Sangwaiya, P Bassett, D Sherman, P Shorvon. Elastography immediately prior to biopsy: Comparison of Ultrasound Elastography scores with histology. Oral presentation at European Society of Gastrointestinal and Abdominal Radiology (ESGAR) meeting May 2011, Venice, Italy

MJ Sangwaiya, A Guimaraes, A Samir, D Sherman, P Shorvon. Imaging of liver fibrosis: Is Ultrasound Elastography the answer? Presented at European Society of Gastrointestinal and Abdominal Radiology (ESGAR) meeting June 2010, Dresden, Germany

MJ Sangwaiya, A Guimaraes, D Sherman, P Shorvon. Imaging of the Liver in liver fibrosis: a User’s Guide. Presented at European Society of Radiology (ESR) meeting 2010

Papers, including in preparation:

MJ Sangwaiya, D Lomas, D Sherman, P Shorvon . Latest developments in the imaging of fibrotic liver disease (accepted for publication in Acta Radiologica, 2013)

D Sherman, K Kandiah, M Jagtiani, A Sharif, P Basset, P Shorvon.Accurate non-invasive prediction of portal hypertension at a single ultrasound procedure using ARFI elastography and a novel “SPVD” score (Final stages of preparation prior to submission to Gut)

Letters to the Editor:

D Sherman, M Jagtiani, P Shorvon. “Non-invasive predictors of portal hypertension” Gastroenterology 2013; 144: 1150-1151.

D Sherman, M Jagtiani, P Shorvon. “Tackling rising rates of liver disease in the UK” BMJ online Feb 2013; 346: f807.

Project publication:

The use of ultrasound elastography for the detection and assessment of liver fibrosis: A technology implementation study within secondary care. NHS Technology Adoption Centre, 2013: www.ntac.nhs.uk/publications/

Teare J., Sherman D., Greenfield S., Simpson J., Bray G., Catterall A., Murray-Lyon I., Peters T., Williams R., Thompson R.  Comparison of serum procollagen III peptide levels and PGA index for the assessment of hepatic fibrosis. Lancet 1993; 342: 895 – 898.

HEPATOLOGY AND GASTROENTEROLOGY

C Lau, C Burd, R Joshi, RD Abeles, D Sherman. Decision making on VTE prophylaxis in acute admissions with chronic liver disease: Is low molecular weight heparin being inappropriately witheld ?  Submitted to British Association for the Study of Liver Disease meeting, London, Sept 2013

R Fofaria, N Hamilton, V Blackwell, D Sherman, A Sharif.

A prospective study on the impact of a ‘bowel cleansing care bundle’ on inpatient

colonoscopy visualisation scores: A London district hospital experience. Gut 2013; 62 Suppl. 1,  A229. Poster presentation at British Society of Gastroenterology meeting, Glasgow, June 2013.

E Neong, M Jacyna, D Sherman, D Peers, L John. A ‘3 in 1’ paperless record for the multidisciplinary management of viral hepatitis in a busy NHS trust. Submitted to British Association for the Study of Liver Disease meeting, London, Sept 2013

A Navarro, A Al-Nowfal, D Sherman, A Martinez-Isla. Choledochal cyst type 6. Presentation at the XII meeting of the Laparoscopic Surgical Section of the Association of Spanish Surgeons, Murcia, April 2013.

Williamson JM, Sherman D, Canelo R. Operative ligation of multiple splenic artery aneurysms. International Surgery. 2008; 93(5) : 261-4.

Costello D., Choudhury R., Sherman D., Abramovich S.  Two cases of oesophageal intramural pseudodiverticulosis. CME Bulletin Otorhinolaryngology, Head & Neck 2004; 8: 29 -31.

Greaves R., Agarwal A., Patch D., Davies S., Sherman D., Reynolds N., Rolles K., Davidson B., Burroughs A.  Inadvertant rechallenge with Diclofenac leading to liver transplantation for fulminant hepatic failure. European Journal of Gastroenterology & Hepatology  2001; 13: 71-4.

Raja K , Pountney D, Bomford A, Przemioslo R, Sherman  D, Simpson R, Williams R, Peters TJ. A duodenal mucosal abnormality in the reduction of Fe(III) in patients with genetic haemochromatosis. Gut  1996; 38: 765 – 769.

Sherman D., Hardman K., Alexander-Williams J., Keighley M., Allan R.  Controlled study of outcome in ileal Crohn’s disease: A comparison of perforating and non-perforating indications for the initial resection. Gut 1994; 36 (Suppl.) A25.

Sherman D., Taylor N., Williams R., Peters T.  Altered cortisol metabolism in alcoholic and non-alcoholic cirrhosis and its relationship to clinical severity of liver disease. Gut 1993; 34 (Suppl.): S7.

ALCOHOL-RELATED LIVER DAMAGE AND ITS MANAGEMENT

Sherman D., Preedy V., Watson R.  Ethanol and the Liver : mechanisms and management. Published by Taylor & Francis, London, June 2002   (A major multi-author publication on all aspects of alcohol and the liver, pp 689, 27 chapters – arguably the most comprehensive publication on the subject to date)

Sherman D., Ward R., Warren-Perry M., Williams R., Peters T.  Association of restriction fragment length polymorphism in alcohol dehydrogenase 2 gene with alcohol – induced liver damage. British Medical Journal 1993; 307: 1388 – 1390.

Sherman D., Dave V., Hsu L., Peters T., Yoshida A.  Diverse polymorphism within a short coding region of the human aldehyde dehydrogensase-5 (ALDH5) gene. Human Genetics 1993; 92: 477 -480.

Sherman D., Williams R.  Liver transplantation for alcoholic liver disease. Journal of Hepatology 1995; 23 (4).

Sherman D., Ward R., Williams R., Peters T.  Emerging markers of predisposition to alcoholism. In: Tabakoff B, Hoffman P ed. Biological Aspects of Alcoholism: Implications for Prevention, Treatment and Policy. New York: Hogrefe & Huber, 1995: 85 – 122.

Kapczinski F., Sherman D., Williams R., Lader M., Curran V.  Flumazenil challenge improves memory in alcoholic patients with cirrhosis. Psychopharmacology 1995; 120: 220-6.

Wassif W., Sherman D., Salisbury J., Peters T.  Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsy in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome. Annals of  Clinical Biochemistry 1994; 31: 462 – 468.

Howard L., Fahy T., Wong P., Sherman D., Gane E., Williams R.  Psychiatric outcome of patients undergoing liver transplantation for alcoholic liver disease. Quarterly Journal of Medicine 1994; 87: 731 – 736.

Ward R., MacPherson A., Chow C., Ealing J., Sherman D., Yoshida A., Peters T.  Identification and characterization of alcohol-induced flushing in Caucasian subjects. Alcohol & Alcoholism 1994; 29: 433 – 438.

Ball D., Sherman D., Gibb R., Powell J., Hillman A., Peters T., Murray R., Smith I.  No association between the C2 allele at the cytochrome P450IIE1 gene and alcohol-induced liver disease, Korsakoff’s encephalopathy and alcohol dependency syndrome. Drug and Alcohol Dependence 1995; 39: 181 – 184.

Sherman D., Ward R., Peters T.  The role of alcohol and aldehyde dehydrogenases in alcohol-related diseases: Clinical studies of molecular markers. In: Weiner H ed. Enzymology and Molecular Biology of Carbonyl Metabolism 4. New York: Plenum, 1993: 595 – 605.

Sherman D., Ward R., Yoshida A., Peters T.  Alcohol and acetaldehyde dehydrogenase gene polymorphism and alcoholism. In: Jansson B., Jornvall H., Rydberg U., Terenius L., Vallee B. ed. Towards a Molecular Basis of Alcohol Use and Abuse. Basel, Switzerland: Birkhauser Verlag, 1994: 291 – 300.

Sherman D., Koskinas J., Williams R. Alcohol and the Liver.  In: Edwards G., Peters T. ed. Alcohol Misuse: A European Perspective. Gordon & Breach, 1995: 63 – 75.

Sherman D., Williams R.  Commentary: Liver transplantation and the alcoholic patient. Alcohol & Alcoholism 1995; 30 (2).

Sherman D., Taylor N., Bird G., Butler J., Williams R., Peters T. Relationship between hypogonadism and testicular atrophy in alcoholic and non-alcoholic liver disease. Alcohol & Alcoholism 1992; 27 (Suppl. 1): 95.

GENERAL INTERNAL MEDICINE

C Lau, C Burd, N Hamilton, MS O’Brien, D Sherman. The unusual presentation of a subdural empyema and its management leading to the incidental treatment of Kimura disease. Presentation to the 1st Annual Educational Excellence Conference, London, October 2012.

Sherman D, Ramsay B, Theodorou NA, Woodrow D, Paradinas FP, Cream J, Murray-Lyon IM. Reversible plane xanthoma, vasculitis, and peliosis hepatis in giant lymph node hyperplasia (Castleman’s disease): a case report and review of the cutaneous manifesations of giant lymph node hyperplasia. J Am Acad Dermatol 1992; 26 (1): 105 – 109.